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NPC2 Antibody, FITC conjugated

Rare Species
Datasheet
Code CSB-PA634688LC01DO
Size US$166
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Product Details

Full Product Name
Rabbit anti-Dog NPC2 Polyclonal antibody
Uniprot No.
Q28895
Target Names
NPC2
Alternative Names
NPC2 antibody; NPC intracellular cholesterol transporter 2 antibody; Epididymal secretory protein E1 antibody; cE1 antibody; Niemann Pick type C2 protein homolog antibody
Raised in
Rabbit
Species Reactivity
Dog
Immunogen
Recombinant Dog NPC intracellular cholesterol transporter 2 protein (22-149AA)
Immunogen Species
Dog
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Related Products

NPC2 Antibodies

NPC2 Proteins

Customer Reviews and Q&A

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Target Background

Function
Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.
Subcellular Location
Secreted. Endoplasmic reticulum. Lysosome.
Protein Families
NPC2 family
Tissue Specificity
Epididymis. High levels are found in the caput and corpus regions. Weaker levels in the distal cauda and in the efferent ducts.
Database Links
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Related Articles
Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?
Related pathways
Cholesterol metabolism Virus Infection
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